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Why Fructose is better than other sweeteners:

- Fructose is "fruit sugar", natural occurring molecule in all fruits, vegetables, honey. 
- Fructose has lowest glycemic index (GI=19) of all natural sugars. For example table sugar (sucrose) GI is 65, and HFCS has GI=68. 
- pure Fructose metabolism differently than refined glucose or High Fructose Corn Syrup (HFCS), and does not require insulin hormone, so it is highly recommended for Diabetes.
- It is officially recommended not only by European Food and Safety Authority, but it's standard Endocrinologists recommendations to Diabetic or pre-Diabetic person to switch to clean fructosa vs other sweeteners.

Sweet Misconceptions: Fructose vs Glucose vs HFCS

There is a great deal of confusion about Fructose, Glucose and High Fructose Corn Syrup (HFCS or "corn sugar"). 

Many incorrectly use the terms “Fructose” and “HFCS” interchangeably, confusing the public as well as health and nutrition professionals. Difference between pure Fructose and HFCS is huge for our body and brain, and it's usually not well understood among non-specialists and general public.

Misinformation about fructose are broadly spread in mainstream media and Internet. The reason is that majority study done in the US is based on HFCS as major ingredient of beverages like Coca-Cola, Pepsi and other carbohydrates drinks (as virtually there is No pure Fructose soft drink on the US market, as pure Fructose is much expensive than HFCS). This misinformation alleges obesity and negative health consequences from the consumption of HFCS.

But HFCS and Fructose act and metabolised differently in human body with completely different health outcomes. It is important to be aware of the differences between these two sweeteners with similar words as fructose. 

Fructose is one of the main types of naturally created sugars found in fruits such as apples, in fruit juices, and in honey.

While, high fructose corn syrup (HFCS) is a mixture of glucose (58%) and fructose (42%), and it is made from corn starch (usually GMO) that has been enzymatically changed. So what about high-fructose corn syrup? Is high-fructose corn syrup (HFCS) healthy too since it contains the same sugar as fruit? Unfortunately, no.

Both glucose and fructose have the same molecular formula, C6H12O6. But the trick is that they are different isomers of the same molecular (differente atoms arrangement). Fructose is ketone, while glucose is aldehyde with different biochemical reactions and outcomes.  

Fructose and glucose metabolism - isotopic tracer

  • Fructose itself is retained (extracted by, held, and processed) in live with very little fructose circulating in the blood stream or delivered to peripheral tissues.
  • While glucose is mainly released into the circulation and utilized peripherally.
  • When fructose was ingested together with glucose, the mean oxidation rate of the mixed sugars increased up to 22%.
  • Human body has much lower insulin response to fructose than glucose. Thus fructosa has been considered more desirable for diabetic diets.

The European Food Safety Authority stated that fructose is preferred over sucrose and glucose in sugar-sweetened foods and beverages because of its lower effect on postprandial blood sugar levels.  

Fructose and glucose differently act on brain

  • Multiple studies provides evidence in humans that fructose and glucose elicits opposite responses in the brain.
  • This neural activity were observed mainly in the cortical control areas, including regions where notions of reward and addiction are processed.  
  • The similar to blood insulin response, glucose sharply increase neural activity for about 20 min (and after sharply decrease).
  • While fructosa intake reduced or keep the same neural activity in the area for about the same amount of time.
  • Fructose ingestion produces smaller increases in cerebral blood flow circulating compared with glucose ingestion.
  • Glucose ingestion (compared with baseline) increased functional connectivity between the hypothalamus and the thalamus and striatum.
  • Fructose increased connectivity between the hypothalamus and thalamus but not the striatum.

Food industry use

Beside that, fructose is an expensive food ingredient and increase price, while HFCS is very cheap and save a lot of money. This is the primary reason why food and beverage industry use HFCS so broadly in their products in order to save money and keep low prices for cheap products. For example, in the United States the corn industry is subsidized and therefore corn is cheap as well as HFCS.

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